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GRB2 ADAPTOR PROTEIN
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DeCS
Descriptor
English
:
GRB2 Adaptor Protein
Descriptor
Spanish
:
Proteína Adaptadora GRB2
Descriptor
Portuguese
:
Proteína Adaptadora GRB2
Synonyms
English
:
Abundant Src Homology Protein
GRB2 Adaptor Protein, Grb3-3 Isoform
Grb3-3 Adaptor Protein
GRB2 Adaptor Protein, Grb3 3 Isoform
Growth Factor Receptor Bound Protein 2
Growth Factor Receptor-Bound Protein-2
Tree Number:
D12.644.360.024.290
D12.776.157.057.026
D12.776.476.024.377
Definition
English
:
A signal transducing adaptor protein that links extracellular signals to the
MAP KINASE SIGNALING SYSTEM
. Grb2 associates with activated
EPIDERMAL GROWTH FACTOR
RECEPTOR and
PLATELET-DERIVED GROWTH FACTOR
RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the
SON OF SEVENLESS PROTEINS
through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
History Note
English
:
2006(1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50766
Unique Identifier:
D051380
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS